A group of aging Gen-Xers, lost in the maze of midlife, come together for a high school reunion. As they journey down memory lane together they discover that they are exactly where they are supposed to be.

Calvin Joyner was voted in high school the guy most likely to succeed. 20 years later he's an accountant. As his high school reunion approaches, he tries to make contact with his old schoolmates. And someone named Bob Stone contacts him. He says that he was known as Robbie Weirdicht in school. Calvin remembers that he was picked on, as a matter of fact after an extremely nasty prank he left school. They agree to meet and Calvin is surprised by how much he has changed. Bob asks Calvin to help him...

The night before their high school reunion, a group of friends realize they still haven't quite grown up in some ways.

Martin Blank is a freelance hitman who starts to develop a conscience, which causes him to muff a couple of routine assignments. On the advice of his secretary and his psychiatrist, he attends his 10th year High School reunion in Grosse Pointe, Michigan (a Detroit suburb where he's also contracted to kill someone). Hot on his tail are a couple of over-enthusiastic federal agents, another assassin who wants to kill him, and Grocer, an assassin who wants him to join an "Assassin's Union."

Over a decade has passed and the gang return to East Great Falls, Michigan, for the weekend. They will discover how their lives have developed as they gather for their high school reunion. How has life treated Michelle, Jim, Heather, Oz, Kevin, Vicky, Finch, Stifler, and Stifler's mom? In the summer of 1999, it was four boys on a quest to lose their virginity. Now Kara is a cute high school senior looking for the perfect guy to lose her virginity to.

Wealthy businessman Ross Webster discovers the hidden talents of Gus Gorman, a mischievous computer genius. Ross decides to abuse his talents, in a way to help Webster with his plans for economic control. When the man of steel interferes, something must be done about Supes. When Gus' synthetic Kryptonite fails to kill Superman, it turns him in an evil incarnation of his former self. The tar-laced Kryptonite pits man against himself, setting up the Clark vs. Superman battle.

A 43 year old mother and housewife that's facing divorce is thrust back in time when she tries to plan a high-school reunion. Given the chance to change the course of her life she finds herself making many of the same choices.